Metzler-Nolte Niels webMEDICINAL INORGANIC CHEMISTRY

Prof. Dr. Nils Metzler-Nolte

Current Position since 2006: Full Professor, Chair of Inorganic Chemistry I – Bioinorganic Chemistry at Ruhr University Bochum.
2000-2006: Associate Professor (C3) for Medicinal Chemistry, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg
1996-2000: Group Leader at the MPI für Strahlenchemie, Mülheim
1994-1995: Postdoc with M. L. H. Green, FRS, University of Oxford
1992-1994: PhD on organoboron chemistry, with H. Nöth at LMU, Munich

Research Interest
Our group has research interests in medicinal organometallic chemistry, functional metal bioconjugates, and most recently biocompatible nanoparticles. We aim to exploit the special properties of metal ocmplexes for the detection and modification of biomolecules. Applications of our research include the development of metal-based drugs, e.g. as anti-cancer and anti-microbial agents. We also study the molecular and cell biology of such metal-based drug candidates. Our group has particular expertise in the synthesis and application of metal-conjugates with bioactive peptides and DNA analogues (e.g. peptide nucleic acids). Such conjugates find applications in targeted drugs as well as in biosensors. The group is running the full program of inorganic chemical synthesis and characterization through to cell culture and biochemical investigations.

Techniques
Our group is well equipped for all kinds of chemical synthesis, including Schlenck lines and glove boxes for air-sensitive compounds. We have particular expertise in manual peptide synthesis, but we also use an automated peptide synthesizer. Characterization methods include, but are not limited to NMR, mass spectrometry, optical, IR, and fluorescence spectroscopy, and electrochemical methods. The group runs our own cell culture lab, where we perform functional assays and determine the cytotoxicity of our compounds, as well as compounds from other groups that we study in collaborations. We also use fluroescence microscopy and flow cytometry to study the uptake and intra-cellular localization of metals and metal bioconjugates.

Selected Reading
Patra M, Gasser G, Metzler-Nolte N. Small Organometallic Compounds as Antibacterial Agents. Dalton Trans 2012, 41, 6350 - 6358; DOI: 10.1039/C2DT12460B.

Gasser G, Metzler-Nolte N. The Potential of Organometallic Complexes in Medicinal Chemistry. Curr Opinion Chem Biol 2012, 16, 84-91; DOI: 10.1016/j.cbpa.2012.01.013.

Gasser G, Sosniak AM, Metzler-Nolte N. Metal-containing peptide nucleic acid conjugates. Dalton Trans 2011, 40, 7061-7076.

Gasser G, Ott I, Metzler-Nolte N. Organometallic Anticancer Compounds. J Med Chem 2011, 54, 3-25.


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