The International Max Planck Research School for Chemical and Molecular Biology (IMPRS-CMB) is a collaboration between the Max Planck Institute of Molecular Physiology and three universities, the Technical University Dortmund (TU Dortmund), the Ruhr University Bochum (RUB) and the University of Duisburg-Essen (DUE).

All four institutes are located in the Ruhr Metropolitan Area of Germany, an extremely vibrant and culturally interconnected region. The same spirit is reflected in the science of our program: research groups, with different and often complementary approaches, combine their efforts to study at the molecular level basic cell physiology.

Below you can find all the research groups that are part of IMPRS-CMB, in alphabetical order. You can also search groups by name, topic or technique.

Read about OUR SCIENCE by visiting the webpages of our Faculty Members.

Bild1 webCHEMISTRY AND BIOCHEMISTRY OF NATURAL PRODUCTS

Prof Dr. Frank Schulz

since 10/2013: Professor of Organic Chemistry at Ruhr University Bochum, Faculty of Chemistry and Biochemistry.
10/2009–09/2013: Beilstein Professor at the Faculty of Chemistry, TU Dortmund, Germany
10/2008–09/2013: Group leader at the Max Planck-Institute of Molecular Physiology, Department of Chemical Biology (Professor H. Waldmann), Dortmund, Germany
06/2007–09/2008: University of Cambridge, Department of Biochemistry; postdoc with Professor P. F. Leadlay.
01/2004–04/2007: PhD-thesis. Supervisor at the Max-Planck-Institute of Coal Research: Professor M. T. Reetz, Thesis title: „Monooxygenases – Experiments to turn a class of enzymes into a toolbox for biocatalysis”.

Research Interest
Natural product chemistry, chemoenzymatic synthesis of bioactive molecules: Investigation of new strategies and methods to manipulate microbial biosynthetic pathways; selective derivatisation of polyketides; microbial and chemoenzymatic synthesis of terpenoids; enzyme engineering; medicinal chemistry.


Techniques
- Enzyme engineering: development of methods and strategies in enzyme mutagenesis
- Partial synthesis of natural product derivatives
- Investigation of natural product bioactivites by suitable bioassays
- Protein purification
- Microbial fermentation
- Microbiology/genetics of filamentous bacteria and yeast
- Biocatalysis

Selected Reading
Sundermann U, Bravo-Rodriguez K, Klopries S, Kushnir S, Gomez H, Sanchez-Garcia E, Schulz F. Enzyme-directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase, ACS Chem Biol 2013, 8(2), 443–450.


Arens J, Engels B, Klopries S, Jennewein S, Ottmann C, Schulz F. Exploration of a biosynthetic access to the shared precursor of the fusicoccane diterpenoid family, Chem Comm 2013, 49 (39), 4337-4339.

Kushnir S, Sundermann U, Yahiaoui S, Brockmeyer A, Janning P, Schulz F. Minimally invasive Mutagenesis gives rise to a Biosynthetic Polyketide Library. Angew Chem Int Ed 2012, 51, 10664–10669.

Kwan DH and Schulz F. The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases. Molecules 2011, 16 (7), 6092-6115.


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