ELUCIDATION OF THE MODE-OF-ACTION OF NATURAL PRODUCTS
Prof. Dr. Markus Kaiser
Current Position: Full professor at the University of Duisburg-Essen, Essen, Germany.
Group Leader: Independent Group Leader at the Chemical Genomics Centre of the Max-Planck-Society, Dortmund, Germany.
Postdoc: with Dr. M.-P. Teulade-Fichou and Prof. Dr. J.-M. Lehn, Collège de France, Paris, France.
PhD: with Prof. Dr. L. Moroder, Max-Planck-Institute of Biochemistry, Martinsried, Germany.
Our group is interested in elucidating the mode-of-action of bioactive compounds, in particular of natural products. To this end, we use preparative organic chemistry as well as chemical proteomics to synthesize, rationally modify and finally to identify the targets of natural products.
Natural product synthesis, (chemical) proteomics, activity-based protein profiling (ABPP), protein expression, enzyme assays
Groll M, Schellenberg B, Bachmann AS, Archer CR, Huber R, Powell TK, Lindow S, Kaiser M, Dudler R. A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature 2008, 452, 755-758.
Clerc J, Groll M, Illich DJ, Bachmann AS, Huber R, Schellenberg B, Dudler R, Kaiser M. Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibition. Proc Natl Acad Sci USA 2009, 106, 6507-6512.
Kaschani F, Clerc J, Krahn D, Bier D, Hong TN, Ottmann C, Niessen S, Colby T, van der Hoorn RA, Kaiser M. Identification of a selective, activity-based probe for GAPDHs. Angew Chem Int Ed 2012, 51, 5230-5233.
Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M. The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chem Biol 2012, 19, 1546-1555.