The International Max Planck Research School for Chemical and Molecular Biology (IMPRS-CMB) is a collaboration between the Max Planck Institute of Molecular Physiology and three universities, the Technical University Dortmund (TU Dortmund), the Ruhr University Bochum (RUB) and the University of Duisburg-Essen (DUE).

All four institutes are located in the Ruhr Metropolitan Area of Germany, an extremely vibrant and culturally interconnected region. The same spirit is reflected in the science of our program: research groups, with different and often complementary approaches, combine their efforts to study at the molecular level basic cell physiology.

Below you can find all the research groups that are part of IMPRS-CMB, in alphabetical order. You can also search groups by name, topic or technique.

Read about OUR SCIENCE by visiting the webpages of our Faculty Members.

gerwert-webCHAIR OF BIOPHYSICS AT RUHR UNIVERSITY BOCHUM

Prof. Dr. Klaus Gerwert

Current Position: since 1993 Chair of Biophysics at the Ruhr-University, Professor (W3), Ruhr University Bochum, Germany
Group Leader: 1990-1993, Heisenberg-fellow, Scripps Research Institute, La Jolla, USA & MPI Dortmund
Postdoc: 1986-1989, Max-Planck-Institute, Dortmund
PhD: 1982-1985, Biophysical Chemistry, University of Freiburg

Research Interest
- Biophotonics
- Molecular Reaction Mechanisms of Proteins
- Role of Protein Bound Water
- Vibrational Imaging of Tissue (FTIR) and Cells (Raman)
- Biomarkers

Techniques
- Protein-Biochemistry
- Time Resolved FTIR & Vibrational Imaging (IR-/Raman-/CARS)
- Biomolecular Simulations (MD & QM/MM)
- X-Ray Crystallography

Selected Reading
Garczarek F, Gerwert K. Functional Waters in Protein Proton Transfer. Nature 2006, 439, 109-112.

Freier E, Wolf S, Gerwert K. Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc Natl Acad Sci USA 2011, 108, 11435-9.

Rudack, T., Fei X., Schlitter, J., Kötting, C. and Gerwert, K. Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc Natl Acad Sci 2012, 109, 15295-15300.

Kallenbach-Thieltges A, Großerüschkamp F, Mosig A, Diem M, Tannapfel A, Gerwert K. Immunohistochemistry, histopathology and infrared spectral histo-pathology of colon cancer tissue sections. J. Biophotonics 2013, 6 (1), 88-100.

El-Mashtoly SF, Petersen D, Yosef HK, Mosig A, Reinacher-Schick A, Kötting C, Gerwert K. Label-Free Imaging of Molecular Targeted Agent Erlotinib in Colon Cancer Cells by Raman Microscopy. Analyst 2014, 139(5), 1155-61.

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