waldmann herbert-webDEPARTMENT OF CHEMICAL BIOLOGY AT THE MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, DORTMUND

Prof. Dr. Herbert Waldmann

Current Position: Director at the Max-Planck-Institute of Molecular Physiology Dortmund, Department of Chemical Biology and Full Professor of Organic Chemistry at the University of Dortmund.
2005 to date: Head of the Chemical Genomics Center of the Max Planck Gesellschaft
1986-1991: Habilitation at the University of Mainz. Obtained tenure in 1991.
1985-1986: Postdoctoral fellow with Prof. George Whitesides at Harvard University, Cambridge, Massachusetts.
1976-1985: Studied chemistry at the University of Mainz. Received a Ph.D. in Organic Chemistry in 1985 under the guidance of Prof. H. Kunz.

Research Interest
Prof. Waldmann’s research interests lie in the analysis of natural product structure for Biology Oriented Synthesis (BIOS) which employs biological relevance and prevalidation to identify novel bioactive compounds for the study of biology. This work includes the design and synthesis of natural product-inspired compound collections and the development of novel enantioselective synthesis methodology, cell-based screening and identification of the cellular targets of bioactive compounds.

A major focus of research in the Waldmann group is on the synthesis of lipidated peptides and proteins in particular of the Ras superfamily and the development of small molecule modulators of their function.

Techniques
Chemical synthesis (general); chemical synthesis of peptides and peptide conjugates; chromatography; combinatorial chemistry in solution and on solid support; enzymes in synthesis: chemoenzymatic protection / deprotection; gas chromatography; in vitro lipidation of proteins; in silico molecular modelling; intein chemistry and in vitro ligation for the generation of fluorescent protein derivatives; liquid chromatography (affinity and gel filtration, e.g. FPLC, HPLC); mass spectrometry (matrix assisted laser desorption ionisation (MALDI), electrospray ionization technique (ESI)); microarray technology; molecular modelling; polarimeter; solid phase synthesis of peptides; synthesis of DNA fragments with a DNA-synthesizer; synthesis of synthetic and semi-synthetic proteins.

Selected Reading
Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PIH, Waldmann, H. Small Molecule Inhibition of the Kras-PDEd Interaction Impairs Oncogenic Kras Signaling. Nature 2013, 497, 638-642.

Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem 2013, 5, 21-28.


Voigt T, Gerding-Reimers C, Ngoc Tran TT, Bergmann S, Lachance H, Schölermann B, Brockmeyer A, Janning P, Ziegler S, Waldmann H. A Natural Product Inspired Tetrahydropyran Collection Yields Mitosis Modulators that Synergistically Target CSE1L and Tubulin. Angew Chem Int Ed 2013, 52, 410-414.

Potowski M, Schürmann M, Preut H, Antonchick AP, Waldmann H. Programmable enantioselective one-pot synthesis of molecules with eight stereocenters. Nat Chem Biol 2012, 8, 428-430.

Potowski M, Bauer JO, Strohmann C, Antonchick AP, Waldmann H. Highy Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides. Angew Chem Int Ed 2012, 51, 9512-9516.

Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, Kumar K, Waldmann H. Natural product-inspired cascade synthesis yields modulators of centrosome integrity. Nat Chem Biol 2012, 8, 179-184.

Hakkim A, Fuchs TA, Martinez NE, Hess S, Prinz H, Zychlinsky A, Waldmann H. Activation of the Raf-MEK-ERK-pathway is required for neutrophil extracellular trap formation. Nat Chem Biol 2011, 7, 75-77.

Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI. The Palmitoylation Machinery is a Spatially Organizing System for Peripheral Membrane Proteins. Cell 2010, 141, 458-471.

Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H. Small molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol 2010, 6, 449-456.

Antonchick AP, Gerding-Reimers C, Catarinella M, Schürmann M, Preut H, Ziegler S, Rauh D, Waldmann H. Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products. Nat Chem 2010, 2, 735-740.

Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G, Waldmann H. Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed 2010, 49, 6090-6095.

Renner S, van Otterlo WA, Dominguez Seoane M, Möcklinghoff S, Hofmann B, Wetzel S, Schuffenhauer A, Ertl P, Oprea TI, Steinhilber D, Brunsveld L, Rauh D, Waldmann H. Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol 2009, 5, 585-592.

Wetzel S, Klein K, Renner S, Rauh D, Oprea TI, Mutzel P, Waldmann H. Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol 2009, 5, 581-583.



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