Bild1 webCHEMISTRY AND BIOCHEMISTRY OF NATURAL PRODUCTS

Prof Dr. Frank Schulz

since 10/2013: Professor of Organic Chemistry at Ruhr University Bochum, Faculty of Chemistry and Biochemistry.
10/2009–09/2013: Beilstein Professor at the Faculty of Chemistry, TU Dortmund, Germany
10/2008–09/2013: Group leader at the Max Planck-Institute of Molecular Physiology, Department of Chemical Biology (Professor H. Waldmann), Dortmund, Germany
06/2007–09/2008: University of Cambridge, Department of Biochemistry; postdoc with Professor P. F. Leadlay.
01/2004–04/2007: PhD-thesis. Supervisor at the Max-Planck-Institute of Coal Research: Professor M. T. Reetz, Thesis title: „Monooxygenases – Experiments to turn a class of enzymes into a toolbox for biocatalysis”.

Research Interest
Natural product chemistry, chemoenzymatic synthesis of bioactive molecules: Investigation of new strategies and methods to manipulate microbial biosynthetic pathways; selective derivatisation of polyketides; microbial and chemoenzymatic synthesis of terpenoids; enzyme engineering; medicinal chemistry.


Techniques
- Enzyme engineering: development of methods and strategies in enzyme mutagenesis
- Partial synthesis of natural product derivatives
- Investigation of natural product bioactivites by suitable bioassays
- Protein purification
- Microbial fermentation
- Microbiology/genetics of filamentous bacteria and yeast
- Biocatalysis

Selected Reading
Sundermann U, Bravo-Rodriguez K, Klopries S, Kushnir S, Gomez H, Sanchez-Garcia E, Schulz F. Enzyme-directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase, ACS Chem Biol 2013, 8(2), 443–450.


Arens J, Engels B, Klopries S, Jennewein S, Ottmann C, Schulz F. Exploration of a biosynthetic access to the shared precursor of the fusicoccane diterpenoid family, Chem Comm 2013, 49 (39), 4337-4339.

Kushnir S, Sundermann U, Yahiaoui S, Brockmeyer A, Janning P, Schulz F. Minimally invasive Mutagenesis gives rise to a Biosynthetic Polyketide Library. Angew Chem Int Ed 2012, 51, 10664–10669.

Kwan DH and Schulz F. The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases. Molecules 2011, 16 (7), 6092-6115.


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