gerwert-webCHAIR OF BIOPHYSICS AT RUHR UNIVERSITY BOCHUM

Prof. Dr. Klaus Gerwert

Current Position: since 1993 Chair of Biophysics at the Ruhr-University, Professor (W3), Ruhr University Bochum, Germany
Group Leader:
1990-1993, Heisenberg-fellow, Scripps Research Institute, La Jolla, USA & MPI Dortmund

Postdoc: 1986-1989, Max-Planck-Institute, Dortmund
PhD:
1982-1985, Biophysical Chemistry, University of Freiburg


Research Interest
- Biophotonics

- Molecular Reaction Mechanisms of Proteins
- Role of Protein Bound Water
- Vibrational Imaging of Tissue (FTIR) and Cells (Raman)
- Biomarkers

Techniques
- Protein-Biochemistry

- Time Resolved FTIR & Vibrational Imaging (IR-/Raman-/CARS)
- Biomolecular Simulations (MD & QM/MM)
- X-Ray Crystallography

Selected Reading
Garczarek F, Gerwert K. Functional Waters in Protein Proton Transfer. Nature 2006, 439, 109-112.


Freier E, Wolf S, Gerwert K. Proton transfer via a transient linear water-molecule chain in a membrane protein. Proc Natl Acad Sci USA 2011, 108, 11435-9.

Rudack, T., Fei X., Schlitter, J., Kötting, C. and Gerwert, K. Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proc Natl Acad Sci 2012, 109, 15295-15300.

Kallenbach-Thieltges A, Großerüschkamp F, Mosig A, Diem M, Tannapfel A, Gerwert K. Immunohistochemistry, histopathology and infrared spectral histo-pathology of colon cancer tissue sections. J. Biophotonics 2013, 6 (1), 88-100.

El-Mashtoly SF, Petersen D, Yosef HK, Mosig A, Reinacher-Schick A, Kötting C, Gerwert K. Label-Free Imaging of Molecular Targeted Agent Erlotinib in Colon Cancer Cells by Raman Microscopy. Analyst 2014, 139(5), 1155-61.

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